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Table 2 Development Cohort Demographics (N = 393)

From: Validation of the novel GLAS algorithm as an aid in the detection of liver fibrosis and cirrhosis based on GP73, LG2m, age, and sex

Characteristic

JHU/UTSMC

(N = 147)

WVC

(N = 246)

Overall

(N = 393)

Healthy

(n = 34)

Fibrosis

(n = 19)

Cirrhosis

(n = 94)

Healthy

(n = 99)

Fibrosis

(n = 59)

Cirrhosis

(n = 88)

Healthy

(n = 133)

Fibrosis

(n = 78)

Cirrhosis

(n = 182)

Age

         

 Median (IQR)

60

(51, 65)

47

(43, 51)

56

(49, 61)

37

(29, 46)

57

(49, 67)

54

(48, 65)

40

(33, 56)

54

(45, 63)

56

(48, 63)

 Range

40, 77

31, 57

23, 73

21, 65

20, 81

26, 94

21, 77

20, 81

23, 94

Sex, n (%)

         

 Male

17

(50%)

16

(84%)

56

(60%)

79

(80%)

27

(46%)

51

(58%)

96 (72%)

43

(55%)

107

(59%)

 Female

17

(50%)

3

(16%)

38

(40%)

20

(20%)

32

(54%)

37

(42%)

37 (28%)

35

(45%)

75

(41%)

Race, n (%)

         

 White

22

(67%)

10

(53%)

53

(58%)

5

(5.1%)

51

(88%)

43

(90%)

27 (20%)

61 (79%)

96

(69%)

 Black

1

(3.0%)

5

(26%)

30

(33%)

94

(95%)

2

3.4%)

1

(2.1%)

95 (72%)

7

(9.1%)

31

(22%)

 Hispanic

0

(0%)

2

(11%)

1

(1.1%)

0

(0%)

4

(6.9%)

2

(4.2%)

0 (0%)

6

(7.8%)

3

(2.1%)

 Asian

0

(0%)

1

(5.3%)

3

(3.3%)

0

(0%)

0

(0%)

0

(0%)

0 (0%)

1

(1.3%)

3

(2.1%)

 Other/Mixed Race

10

(30%)

1

(5.3%)

5

(5.4%)

0

(0%)

1

(1.7%)

2

(4.2%)

10 (7.6%)

2

(2.6%)

7

(5.0%)

 Unknown

1

0

2

0

1

40

1

1

42

Etiology, n (%)

—

  

—

  

—

  

 Viral

 

  HBV

 

0

(0%)

13

(14%)

 

0

(0%)

20

(23%)

 

0

(0%)

33

(18%)

  HCV

 

0

(0%)

41

(44%)

 

0

(0%)

22

(25%)

 

0

(0%)

63

(35%)

 Non-Viral

 

  Alcoholic Liver Disease

 

0

(0%)

0

(0%)

 

8

(14%)

0

(0%)

 

8

(10%)

0

(0%)

  Fatty Liver Disease

 

0

(0%)

0

(0%)

 

33

(56%)

0

(0%)

 

33

(42%)

0

(0%)

  Hemochromatosis

 

0

(0%)

0

(0%)

 

8

(14%)

0

(0%)

 

8

(10%)

0

(0%)

  Simple Steatosis

 

0

(0%)

0

(0%)

 

6

(10%)

0

(0%)

 

6

(7.7%)

0

(0%)

  Non-Viral Cirrhosis

 

0

(0%)

40

(43%)

 

0

(0%)

0

(0%)

 

0

(0%)

40 (22%)

 Unknown

 

19

(100%)

0

(0%)

 

4

(6.8%)

46

(52%)

 

23

(29%)

46

(25%)

  1. JHU, Johns Hopkins University School of Medicine; UTSMC, University of Texas Southwestern Medical Center; WVC, Western Vendor Cohort; IQR, interquartile range; HBV, hepatitis B virus; HCV, hepatitis C virus