Table 4 Diagnostic Performance of Biomarkers Alone and in Combination with Clinical Factors in the Development Cohort (JHU/UTSMC/WVC) and Model 5 in the Validation Cohort (PUMCH)
|  | Model | Predictor Variables | N | Events (n) | AUC | AUC 95% CI | SE (%) | SP (%) | SE (SP = 90%) | SP (SE = 90%) | SP (SE = 75%) |
Development Cohort | 1 | GP73 | 393 | 260 | 0.86 | (0.82, 0.89) | 82.7 | 64.7 | 68.8 | 47.4 | 78.9 |
2 | LG2m | 393 | 260 | 0.83 | (0.79, 0.87) | 81.9 | 60.9 | 66.5 | 32.3 | 79.7 | |
3 | GP73 + Age + Sex | 393 | 260 | 0.91 | (0.89, 0.94) | 89.6 | 73.7 | 76.2 | 73.7 | 91.7 | |
4 | LG2m + Age + Sex | 393 | 260 | 0.88 | (0.85, 0.92) | 88.5 | 75.9 | 61.9 | 72.9 | 84.2 | |
5 | GP73 + LG2m + Age + Sex (GLAS) | 393 | 260 | 0.92 | (0.90, 0.95) | 88.8 | 75.9 | 79.2 | 73.7 | 94.7 | |
|  | Model | Etiology | N | Predicted Events (n) | AUC | AUC 95% CI | SE (%) | SP (%) | SE (SP = 90%) | SP (SE = 90%) | SP (SE = 75%) |
Validation Cohort | 5 (GLAS)* | All Fibrosis/Cirrhosis | 354 | 248 | 0.93 | (0.90, 0.95) | 91.1 | 80.2 | 81.0 | 82.1 | 93.4 |
Viral | 158 | 52 | 0.91 | (0.86, 0.96) | 88.5 | 80.2 | 75.0 | 81.1 | 91.5 | ||
Non-viral | 252 | 146 | 0.94 | (0.91, 0.97) | 93.2 | 80.2 | 86.3 | 84.9 | 93.4 | ||
Unknown Etiology | 156 | 50 | 0.91 | (0.86, 0.96) | 88.0 | 80.2 | 74.0 | 73.6 | 89.6 | ||
Chronic Liver Disease | 253 | 147 | 0.65 | (0.58, 0.71) | 42.9 | 80.2 | 26.5 | 15.1 | 39.6 | ||
All Liver Disease | 501 | 395 | 0.82 | (0.78, 0.86) | 73.2 | 80.2 | 61.0 | 36.8 | 76.4 |