Fig. 7

Cytokine-JAK-STAT signaling underlying COVID-19. A Differential expression of cytokines and chemokines in the COV-D1, ICU and HC PMBCs. Data shown were normalized to β-actin to calculate relative fold change in mRNA transcripts. Asterisks indicate significant difference between COV_D1 and ICU or HC unless otherwise specified. *p < 0.05, **p < 0.002, based on One-Way ANOVA (n = 5, 4 technical repeats). B A cytokine-JAK-STAT signaling network showing significant changes in protein expression or phosphorylation based on the MS data. The proteins and phosphosites are colored according to the COV-D1/HC ratio (red: upregulation, blue: downregulation). The nodes without sufficient data to calculate the ratio are colored grey. The phosphosites with an asterisk indicate activity-inducing residues