Closing the gaps in patient management of dyslipidemia: stepping into cardiovascular precision diagnostics with apolipoprotein profiling

Table 2 Receptors, enzymes and transporter proteins and their interaction either (+) activated or (-) inhibited by apolipoproteins in lipid metabolism

	Involved particle	Essential apo	Ref
Receptor
LDLR	LDL	ApoB-100	[20]
	VLDL, IDL	ApoE ApoB-100 lesser degree than ApoE	[21]
	CM	ApoE	[21]
	Remnants	ApoE ApoB-100 lesser degree than ApoE	[21]
VLDLR	VLDL, IDL	ApoE	[21]
	CM	ApoE	[21]
	Remnants	ApoE	[21]
LRP1	VLDL, IDL	ApoE	[22]
	Remnants	ApoE	[21]
	CM	ApoE	[21]
SR-B1	HDL	ApoA-I Free ApoE	[23, 24]
Enzyme
HL	VLDL, IDL	ApoE (+)	[25]
HL	HDL	ApoE (+) ApoC-I (-)	[26, 27]
LPL	VLDL, IDL	ApoC-I (-) ApoC-II (+ or - depending on its concentration) ApoC-III(-)	[28, 29, 30, 31, 32]
LCAT	HDL	ApoA-I (+) ApoA-IV (+) ApoC-I (+)	[27, 33]
Transporter protein
ABCA1	HDL	ApoA-I (+) ApoE (+)	[34, 35]
CETP	VLDL, CM, HDL	ApoC-I on HDL (-)	[36]

ISSN: 1559-0275